Center Publications

Project 1: Prospective Study of the Onset of Schizophrenia

  1. McClure RK, Lieberman JA. Neurodevelopmental and Neurodegenerative Hypotheses of Schizophrenia: A Review and Critique. Current Opinion in Psychiatry 2003; 16 [Suppl 2]:S15-S28.
  2. Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J et al. Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 2003; 29(4):703-715.
  3. Pinkham AE, Penn DL, Perkins DO, Lieberman J. Implications for the neural basis of social cognition for the study of schizophrenia. Am J Psychiatry 2003; 160(5):815-824.
  4. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60(12):1187-1192.
  5. Szeszko PR, Gunning-Dixon F, Ashtari M, Snyder PJ, Lieberman JA, Bilder RM. Reversed cerebellar asymmetry in men with first-episode schizophrenia. Biol Psychiatry 2003; 53(5):450-459.
  6. Szeszko PR, Gunning-Dixon F, Goldman RS, Bates J, Ashtari M, Snyder PJ et al. Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophrenia. Am J Psychiatry 2003; 160(10):1884-1887.
  7. Woods SW, Breier A, Zipursky RB, Perkins DO, Addington J, Miller TJ et al. Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome. Biol Psychiatry 2003; 54(4):453-464.
  8. Hawkins KA, Addington J, Keefe RS, Christensen B, Perkins DO, Zipurksy R et al. Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophr Res 2004; 67(2-3):115-122.
  9. Inan S, Mitchell T, Song A, Bizzell J, Belger A. Hemodynamic correlates of stimulus repetition in the visual and auditory cortices: an fMRI study. Neuroimage 2004; 21(3):886-893.
  10. Perkins DO. Evaluating and treating the prodromal stage of schizophrenia. Curr Psychiatry Rep 2004; 6(4):289-295.
  11. van der Stelt O, Belger A, Lieberman JA. Macroscopic fast neuronal oscillations and synchrony in schizophrenia. Proc Natl Acad Sci U S A 2004; 101(51):17567-17568.
  12. van der Stelt O, Frye J, Lieberman JA, Belger A. Impaired P3 generation reflects high-level and progressive neurocognitive dysfunction in schizophrenia. Arch Gen Psychiatry 2004; 61(3):237-248.
  13. Mitchell TV, Morey RA, Inan S, Belger A. Functional magnetic resonance imaging measure of automatic and controlled auditory processing. Neuroreport 2005; 16(5):457-461.
  14. Morey RA, Inan S, Mitchell TV, Perkins DO, Lieberman JA, Belger A. Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. Arch Gen Psychiatry 2005; 62(3):254-262.
  15. Shafritz KM, Kartheiser P, Belger A. Dissociation of neural systems mediating shifts in behavioral response and cognitive set. Neuroimage 2005; 25(2):600-606.
  16. van der Stelt O, Lieberman JA, Belger A. Auditory P300 in high-risk, recent-onset and chronic schizophrenia. Schizophr Res 2005; 77(2-3):309-320.
  17. Keefe RSE, Perkins DO, Gu H, Zipursky RB, Christensen BK, Lieberman JA. A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophr Res 2006; 88(1-3):26-35.
  18. van der Stelt O, Belger A. Attentional modulation of early-stage visual processing in schizophrenia. Brain Res 2006; 1125(1):194-8.

 

Project 2:  Early Brain Development in High Risk Children

  1. Zhai G, Lin W, Wilber KP, Gerig G, Gilmore JH. Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 2003; 229(3):673-681.
  2. Gilmore JH, Zhai G, Wilber K, Smith JK, Lin W, Gerig G. 3 Tesla magnetic resonance imaging of the brain in newborns. Psychiatry Res 2004; 132(1):81-85.
  3. Prastawa M, Gilmore JH, Lin WL, Gerig G. Automatic segmentation of MR images of the developing newborn brain. Medical Image Analysis 2005; 9(5):457-466.
  4. Corouge I, Fletcher PT, Joshi A, Gilmore JH, Gerig G. Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005; 8:131-139.
  5. Hazlett HC, Poe MD, Gerig G, Smith RG, Provenzale J, Ross A, Gilmore JH, Piven J. An MRI and head circumference study of brain size in autism: birth through age two years. Arch Gen Psychiatry 2005; 62: 1366-1376.
  6. Goodlett C, Davis B, Jean R, Gilmore J, Gerig G. Improved Correspondence for DTI Population Studies via Unbiased Atlas Building., Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2006; 9(Pt 2):260-7.
  7. Gilmore JH, Lin W, Gerig G. Fetal and Neonatal Brain Development. Am J Psychiatry 2006; 163:12.
  8. Looney CB, Smith JK, Fagan LH, Wolfe HM, Chescheir NC, Hamer RM, Gilmore JH. Intracranial hemorrhage in asymptomatic neonates: prevalence on MR scans and relationship to obstetric and neonatal risk factors. Radiology 2007; 242(2):535-41.
  9. Gilmore JH, Lin W, Prastawa MW, Looney CB, Vetsa YSK, Knickmeyer RC, Evans DD, Smith JK, Hamer RM, Lieberman JA, Gerig G. Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain. J Neuroscience 2007; 27(6):1255-60.

Project 3:  Postmortem Study of Cortical Circuit Development

  1. Glantz LA, Gilmore JH, Lieberman JA, Jarskog LF.  Apoptotic mechanisms and the synaptic pathology of schizophrenia.  Schizophr Res 2005; 81:47-63.
  2. Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29(5):846-858.
  3. Jarskog LF, Miyamoto S, Lieberman JA.  Schizophrenia:  New Pathological Insights and Therapies.  Annu. Rev. Med. 2007; 58:59-71.

Project 4:  Mechanisms of Cortical GABA Interneuron Differentiation

Maness Laboratory

  1. Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc Natl Acad Sci U S A 2003; 100(24):14433-14438.
  2. Panicker AK, Buhusi M, Thelen K, Maness PF. Cellular signalling mechanisms of neural cell adhesion molecules. Front Biosci 2003; 8:d900-d911.
  3. Demyanenko GP, Schachner M, Anton E, Schmid R, Feng G, Sanes J et al. Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron 2004; 44(3):423-437.
  4. Irintchev A, Koch M, Needham LK, Maness P, Schachner M. Impairment of sensorimotor gating in mice deficient in the cell adhesion molecule L1 or its close homologue, CHL1. Brain Res 2004; 1029(1):131-134.
  5. Schmid RS, Midkiff BR, Kedar VP, Maness PF. Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling. Neuroreport 2004; 15(18):2791-2794
  6. Diestel S, Hinkle CL, Schmitz B, Maness PF. NCAM140 stimulates integrin-dependent cell migration by ectodomain shedding. J Neurochem 2005; 95:1777-1784.
  7. Pillai-Nair N, Panicker AK, Rodriguiz RM, Gilmore KL, Demyanenko GP, Huang JZ, Wetsel WC, Maness PF. Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. J Neurosci 2005; 25(18):4659-4671.
  8. Panicker AP, Buhusi M, Erickson A, Maness PF. Endocytosis of ß1 Integrins is an Early Event in Migration Promoted by the Cell Adhesion Molecule L1. Exp Cell Res 2006; 312:299-307.
  9. Sullivan PF, Keefe RSE, Lange LA, Lange EM, Stroup TS, Lieberman J, Maness PF.  NCAM1 and Neurocognition in Schizophrenia. Biol Psychiatry 2007; 61(7):902-10.

LaMantia Laboratory

  1. Maynard TM, Haskell GT, Lieberman JA, LaMantia AS. 22q11 DS: genomic mechanisms and gene function in DiGeorge/velocardiofacial syndrome.  Int J Dev Neurosci 2002; 20(3-5):407-19. Review.
  2. Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS.  A comprehensive analysis of 22q11 gene expression in the developing and adult brain.  Proc Natl Acad Sci U S A 2003; 100(24):14433-8.
  3. Miyamoto S, LaMantia AS, Duncan GE, Sullivan P, Gilmore JH, Lieberman JA. Recent advances in the neurobiology of schizophrenia.  Molecular Interventions 2003; 3: 27-39.
  4. Haskell GT, LaMantia AS.  Retinoic acid signaling identifies a distinct precursor population in the developing and adult forebrain. J Neurosci 2005 Aug 17;25(33):7636-47.
  5. Councill JH, Tucker ES, Haskell GT, Maynard TM, Meechan DW, Hamer RM, Lieberman JA, LaMantia AS.  Limited influence of olanzapine on adult forebrain neural precursors in vitro. Neuroscience 2006; 140(1):111-22.
  6. Maynard TM, Meechan DW, Heindel CC, Peters AZ, Hamer RM, Lieberman JA, LaMantia AS.  No evidence for parental imprinting of mouse 22q11 gene orthologs. Mamm Genome 2006;17(8):822-32.
  7. Meechan DW, Maynard TM, Wu Y, Gopalakrishna D, Lieberman JA, LaMantia A-S.  Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Molecular and Cellular Neuroscience 2006; 33(4):412-28.
  8. Tucker ES, Polleux F, LaMantia AS.  Position and time specify the migration of a pioneering population of olfactory bulb interneurons. Dev Biol. 2006; 297(2):387-401.
  9. Meechan DW, Maynard TM, Gopalakrishna D, Wu Y, LaMantia A-S.  When half is not enough: Gene expression and dosage in the 22q11 deletion syndrome. Gene Expression, In Press.    

Administrative Core

  1. Miyamoto S, LaMantia AS, Duncan GE, Sullivan P, Gilmore JH, Lieberman JA. Recent advances in the neurobiology of schizophrenia. Mol Interv 2003; 3(1):27-39.
  2. Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 2005; 10(1):79-104.

Neuroimaging Core

  1. Joshi S, Lorenzen P, Gerig G, Bullitt E. Structural and radiometric asymmetry in brain images. Med Image Anal 2003; 7(2):155-170.
  2. Lin W, An H, Chen Y, Nicholas P, Zhai G, Gerig G, Gilmore J, Bullitt E. Practical consideration for 3T imaging. Magn Reson Imaging Clin N Am. 2003; 11(4):615-39.
  3. Pizer SM, Gerig G, Joshi S, Aylward SR. Multiscale medial shape-based analysis of image objects. IEEE Trans Med Imaging 2003; 91(10):1670-1679.
  4. Styner M, Gerig G, Joshi S, Pizer S. Automatic and robust computation of 3D medial models incorporating object variability. International Journal of Computer Vision 2003; 55(2-3):107-122.
  5. Styner M, Gerig G, Lieberman J, Jones D, Weinberger D. Statistical shape analysis of neuroanatomical structures based on medial models. Med Image Anal 2003; 7(3):207-220.
  6. Zhai G, Lin W, Wilber KP, Gerig G, Gilmore JH. Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit. Radiology 2003; 229(3):673-681.
  7. Corouge I, Gouttard S, Gerig G. A statistical shape model of individual fiber tracts extracted from diffusion tensor MRI. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2004, Pt 2, Proceedings 2004; 3217:671-679.
  8. Corouge I, Gouttard S, Gerig G. Towards a shape model of individual fiber bundles using diffusion tensor MRI. International Symposium on Biomedical Imaging 2004;344-347.
  9. Davis B, Lorenzen P, Joshi S. Large deformation minimum mean squared error template estimation for computational anatomy. IEEE International Symposium on Biomedical Imaging 2004.
  10. Gerig G, Gouttard S, Corouge I. Analysis of brain white matter via fiber tract modeling. IEEE Engineering in Medicine and Biology 2004; IEEE Catalog No: 04CH37558C:426.
  11. Inan S, Mitchell T, Song A, Bizzell J, Belger A. Hemodynamic correlates of stimulus repetition in the visual and auditory cortices: an fMRI study. Neuroimage 2004; 21(3):886-893.
  12. Joshi S, Davis B, Jomier M, Gerig G. Unbiased diffeomorphic atlas construction for computational anatomy. Neuroimage 2004; 23 Suppl 1:S151-S160.
  13. Lorenzen P, Davis B, Gerig G, Bullitt E, Joshi S. Multi-class posterior atlas formation via unbiased Kullback-Leibler template estimation. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2004, Pt 1, Proceedings 2004; 3216:95-102.
  14. Prastawa M, Gilmore J, Lin WL, Gerig G. Automatic segmentation of neonatal brain MRI. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2004, Pt 1, Proceedings 2004; 3216:10-17.
  15. Styner M, Lieberman JA, Pantazis D, Gerig G. Boundary and medial shape analysis of the hippocampus in schizophrenia. Med Image Anal 2004; 8(3):197-203.
  16. Corouge I, Fletcher PT, Joshi S, Gilmore JH, Gerig G. Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis. MICCAI 2005, LNCS 2005; 3749:131-139.
  17. Lorenzen P, Prastawa M, Davis B, Gerig G, Bullitt E, Joshi S. Multi-modal image set registration and atlas formation. Med Image Anal 2005; Epub ahead of print.
  18. Mitchell TV, Morey RA, Inan S, Belger A. Functional magnetic resonance imaging measure of automatic and controlled auditory processing. Neuroreport 2005; 16(5):457-461.
  19. Mortamet B, Zeng D, Gerig G, Prastawa M, Bullitt E. Effects of healthy aging measured by intracranial compartment volumes using a designed MR brain database. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2005;8(Pt 1):383-91.
  20. Steen RG, Hamer RM, Lieberman JA. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 2005; 30(11):1949-1962.
  21. Styner M, Lieberman JA, McClure RK, Weinberger DR, Jones DW, Gerig G. Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. Proc Natl Acad Sci U S A 2005; 102(13):4872-4877.
  22. Corouge I, Fletcher PT, Joshi S, Gouttard S, Gerig G. Fiber Tract-Oriented Statistics for Quantitative Diffusion Tensor MRI Analysis, Isabelle Corouge, P.Thomas Fletcher, Sarang Joshi, Sylvain Gouttard, Guido Gerig. Med Image Anal. 2006; 10(5):786-98. 
  23. Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, Gerig G. User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage. 2006; 31(3):1116-28.
  24. Steen RG, Mull C, McClure R, Hamer RM, Lieberman JA. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 2006; 188:510-8.

  25. Cascio CJ, Gerig G, Piven J. Diffusion Tensor Imaging: Application to the Study of the Developing Brain. Journal of the American Academy of Child and Adolescent Psychiatry JAACAP 2007; 46(2):213-23.